An innovative approach to joint health made possible through research, dedication, and continued improvement.

Innovation, integrity, leadership, and a genuine care for our customers – these are the drivers behind what we do at 4CYTE™. Interpath (the creators of 4CYTE™) are a research and development company committed to pioneering joint health research and exploration in our field, leading us to create innovative products that drive change within our industry.

Since 2008, 4CYTE™ and Epiitalis® have undergone rigorous assessments to test their safety and efficacy in laboratory, in vivo, and clinical trials across multiple species including dogs, horses and humans. Many of these studies have been peer reviewed and published in leading international journals.

Below, you’ll find a selection of scientific highlights from a growing body of evidence that supports the safety and efficacy of 4CYTE™ and Epiitalis®. These excerpts have been highly summarised. If you are interested in learning more, please download the full publications using the links below each excerpt, visit our FAQ page, or get in touch with our team.


Canine Science

A new leash on life: 4CYTE™ Epiitalis® Forte Dog prevents and treats symptoms of osteoarthritis in dogs

The study

A pilot study of 4CYTE™ Epiitalis® Forte Dog, a novel nutraceutical, in the management of naturally occurring osteoarthritis in dogs

T Beths,* R Munn, SH Bauquier, P Mitchell and T Whittem


of dogs who used 4CYTE™ showed improvement in their quality of life*


of dogs who used 4CYTE™ showed an improvement in movement and also showed an improvement in quality of life.*


of dogs who used 4CYTE™ showed improvement in movement*


of dogs using prescription OA medications showed further improvement when 4CYTE™ was added to their treatment regime*

The study design: 

In a peer reviewed and published clinical trial conducted at Melbourne University in 2020, 4CYTE™ Epiitalis® Forte Dog was assessed in a one-month pilot study involving 46 dogs with naturally occurring osteoarthritis.

Two data collection tools were used. Gait analysis using the GaitRite walkway system collected objective data by measuring paw strike as the dogs walked over a 5m mat with sensors. The sorest limb, or paw exerting least pressure was identified as the study limb. Dogs completed 3 “passes” across the mat. The Helsinki Chronic Pain Index (HCPI) which asked a series of 11 quality of life-based questions, collected subjective data.

Study dogs were assessed on Day 0 and then sent home with 4CYTE™ Epiitalis® Forte Dog. Dogs returned 28 days later to complete their 2nd assessment.

Summary of results:

At day 28:

  • 74% of dogs improved the pressure placed on the sore limb, suggesting that there had been a reduction in pain.
  • 93.5% of dogs improved their “Quality of life” score from the HCPI assessment, indicating reduction in pain and improvement in demeanour.
  • 71% of dogs that were on concurrent osteoarthritis medication throughout the study, improved further.

This trial suggests that 4CYTE™ Epiitalis® Forte Dog successfully reduced symptoms of osteoarthritis in dogs.

Equine Science

Epiitalis® demonstrates disease modifying effects in equine osteoarthritis study – a world first, scientific breakthrough

The study

Examining the effects of an extract of Biota Orientalis (BO) in the osteochondral fragment-exercise model of osteoarthritis.

Kathryn A. Seabaugh, Myra F. Barrett, C. Wayne McIlwraith, David D. Frisbie.

Dorsolatero-palmaromedial oblique radiographs of a placebotreated horse (A) and Epiitalis® treated horse (B) on Day 70.

Osteochondral fragment visible in both horses.Sclerosis of third carpal bone and radiocarpal bone are visible in placebo-treated treated horse as well as enthesopathy of the joint capsule, and osteophytosis. Soft tissue swelling representing middle carpal joint effusion is the only common abnormality between the two horses.

Summary of results:

An assessment of the efficacy of Epiitalis® in a surgically induced equine model of OA demonstrated significant symptom-modifying and disease-modifying effects following oral treatment with Epiitalis®. Not only was potent management of local inflammation observed, but also obvious amelioration of X-ray measured OA-changes with a significant decrease in radiographic evidence of osteoarthritis.


Significant symptom-modifying and disease-modifying effects were seen following oral treatment with Epiitalis® in this equine in vivo model of osteoarthritis. The most significant results were related to the decreased concentration of PGE2 in synovial fluid and amelioration of radiographic changes in horses treated with 4CYTE™ Epiitalis® Forte Horse.

Improvement in just 1 week with 4CYTE™ Epiitalis® Forte Horse

The study

To establish the clinical efficacy of dose rates in Epiitalis® in a gel oral application and its ability to reduce arthritis symptoms | Dr Frederick W. Benker et al, Equine Medical Centre of Ocala

The study design:

Ten horses were selected showing signs of arthritis or joint effusion. They were randomly allocated to two treatment groups for 42 days. One group received 8g from day 1-14, then 4g from day 15-42. The second group received 8g from day 1-28 then 4g from day 29-42.

Summary of results:

Lameness: 7 of the 10 horses had a consistent lameness at day 0. 8 of the 10 horses at day 14 had an absent or difficult to observe lameness. Only 1 horse had a subtle limp after 42 days.

Heat and Swelling: 6 of the 10 horses had significant heat and swelling at Day 0. 8 of the 10 horses were only showing nominal to absent levels after 14 days.

Range of Movement: 8 of 10 horses had a significant reduction in range of movement/mobility at Day 0. At day 14, only 8 horses were showing full range or a slight reduction in range of movement/mobility. At Day 42, 9 of the 10 horses had full range of movement mobility.


Within one week of treatment the levels of improvement were hugely significant in all 9 of the horses.

    Your cart is emptyReturn to Shop